# RESPONSE OF CANINE TUMORS TO NONSTANDARD FRACTIONATION

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 1988 · $152,198

## Abstract

This study will be done with naturally occurring nasal carcinomas in dogs.
The purpose is to evaluate the radiation response of tumor and acute and
late responding normal tissues to nonconventional fractionation schemes.
It has been proposed that accelerated fractionation of the radiation
therapy dose might be more effective for control of rapidly proliferating
tumors.  It has also been proposed that some reduction in late normal
tissue complications could be achieved with smaller doses per fraction.  If
the intertreatment interval between fractions and the overall time to give
a total dose of radiation can be reduced, tumors would have less
opportunity for repopulation and regrowth.  If the dose response curves of
target cells for acute and late responding normal tissues are significantly
different, late responding normal tissues may be spared by smaller doses
per fraction while acutely responding tissues will not experience a
corresponding decrease in injury.  Tumors are considered to be acutely
responding tissues.  The research proposed is designed to test the theory
and to give estimates of the general shapes of dose response curves for
tumor and acute and late responding tissues.  Variable total doses will be
given to three groups of dogs with nasal carcinomas.  Each group will
receive a different size of dose per fraction to achieve the variable total
doses.  All irradiation doses will be given in an interval of four weeks.
Analysis will be done to determine the 50% probability for tumor control at
one year; the probability for levels of response of acutely responding
tissues, particularly the structures of the eye; and probability for late
necrosis.  The data will permit evaluation of the effect of size of dose
per fraction on total dose required for tumor control, early effects and
late complications.  Isoeffect curves will be constructed for the various
tissues using data obtained from each of the three different dose per
fraction groups.

## Key facts

- **NIH application ID:** 3174662
- **Project number:** 5R01CA036992-04
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **SAM.gov UEI:** LT9CXX8L19G1
- **Principal Investigator:** EDWARD L GILLETTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $152,198
- **Award type:** 5
- **Project period:** 1985-07-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174662

## Citation

> US National Institutes of Health, RePORTER application 3174662, RESPONSE OF CANINE TUMORS TO NONSTANDARD FRACTIONATION (5R01CA036992-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174662. Licensed CC0.

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