# SYNTHESIS OF ANTICANCER MEMBRANE DITERPENES

> **NIH NIH R01** · CORNELL UNIVERSITY · 1988 · $137,194

## Abstract

The cembrane diterpenes are a large class natural products that
contain a 14-membered ring.  Many members of the class -
lobohedliolide, crassin, sinularin, dihydrosinularin, and others -
show considerable anticancer activity, both in vivo and in vitro.
In spite of this biological activity, relatively little synthetic work
has been carried out in the field, probably because few methods of
synthesis exist for preparing large-ring carbocycles.

This proposal puts forward a plan for the synthesis of
representative cembrenoids utilizing new methods developed in
the P.I.'s laboratory for the synthesis of large-ring cycloalkenes,
large-ring 1, 2-diols, and large-ring ketones.  Specifically, plans
are put forward for the total synthesis of isocembranolide,
sinularin, and crassin.  By preparing these compounds, these
natural products and their analogs will become more readily
available and chemical knowledge of reaction selectivity in large-
ring carbocycles will be extended.

## Key facts

- **NIH application ID:** 3174685
- **Project number:** 5R01CA037005-05
- **Recipient organization:** CORNELL UNIVERSITY
- **SAM.gov UEI:** G56PUALJ3KT5
- **Principal Investigator:** JOHN E MC MURRY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $137,194
- **Award type:** 5
- **Project period:** 1984-03-01 → 1990-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174685

## Citation

> US National Institutes of Health, RePORTER application 3174685, SYNTHESIS OF ANTICANCER MEMBRANE DITERPENES (5R01CA037005-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174685. Licensed CC0.

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