# FREDERICAMYCIN A: ANALOGS TO PROBE MECHANISM OF ACTION

> **NIH NIH R01** · BOSTON COLLEGE · 1989 · $122,969

## Abstract

Fredericamycin A is a highly functionalized hexacyclic molecule
whose unusual structure was reported in 1982.  In vitro and in vivo
biological studies have established its exceptionally high activity
in a wide variety of anticancer screens and, as a consequence,
Fredericamycin A is being very seriously considered for clinical
evaluation for the treatment of human cancers.  Because of its
novel structure Fredericamycin is also a valuable structural lead
for new chemotherapeutic agents.  Nothing is known, however,
about Fredericamycin A's mechanism of action.

We have very recently completed the first synthesis of
Fredericamycin A.  The objective of the proposed work is to apply
the chemical knowledge acquired during the course of the
synthesis to prepare by total synthesis a variety of structural
analogs designed to determine Fredericamycin A's mechanism of
action, which should allow the preparation of analogs which are
therapeutically superior to Fredericamycin.

## Key facts

- **NIH application ID:** 3174723
- **Project number:** 5R01CA037054-06
- **Recipient organization:** BOSTON COLLEGE
- **SAM.gov UEI:** MJ3JH8CRJBZ7
- **Principal Investigator:** T. ROSS KELLY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $122,969
- **Award type:** 5
- **Project period:** 1984-03-01 → 1990-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174723

## Citation

> US National Institutes of Health, RePORTER application 3174723, FREDERICAMYCIN A: ANALOGS TO PROBE MECHANISM OF ACTION (5R01CA037054-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174723. Licensed CC0.

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