# RECEPTORS FOR IMMUNOGLOBULIN G ON LEUKOCYTES

> **NIH NIH R01** · WISTAR INSTITUTE · 1990 · $207,149

## Abstract

Receptors for IgG (FcR) are present on leukocytes effector of
non-adaptive systems of defense against pathogenes, and they
function as linking structures between the intra- and extracellular
compartments.  By binding specific immunoglobulins or antigen-
antibody complexes, FcR allow the targeting of non-immune cells
activities by the specific proteins of the immune response.  FcR-
ligand interaction and several lymphokines both variably modulate
the functions of these cells in resistance to pathogens, and the
surface expression of receptors for IgG and for other molecules
(e.g. growth factors).  Our data indicate that the interaction of
membrane FcR (CD16 antigen) of natural killer (NK) cells with
their specific ligand or with monoclonal anti-CD16 antibodies that
mimic the ligand eventually results in either or both activation
and inactivation of NK cells, as evidentiated by ultrastructural
changes, novel mRNA transcription and modulation of both FcR-
dependent and -independent functions.  Our working hypothesis is
that the low affinity FcR on NK cells act as signal-transducing
structures upon interaction with their ligands.  To test this, we
will:  a) determine the mechanism(s) by which FcR-ligand
interactions impart activation signals to the cells at the
molecular level, b) analyze the role of CD16 molecule as ligand-
dependent ion channel, c) dissect the mechanism by which FcR-
ligand interactions induce modulation of cytotoxic and
proliferative potential of human NK cells.  To define unifying or
distinctive features of behaviour of FcR and FcR-dependent
functions of different cells of the non-adaptive system of defense,
we will compare the functional properties of FcR on NK cells
with those of a similar FcR type on granulocytes.  Experiments
will also be performed to determine whether the high affinity FcR
on monocytes and cytokine-activated granulocytes, like the CD16
molecule on NK cells and PMN.

## Key facts

- **NIH application ID:** 3174896
- **Project number:** 5R01CA037155-06
- **Recipient organization:** WISTAR INSTITUTE
- **SAM.gov UEI:** DW1XZMGNFBL4
- **Principal Investigator:** BICE PERUSSIA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $207,149
- **Award type:** 5
- **Project period:** 1984-04-01 → 1991-01-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174896

## Citation

> US National Institutes of Health, RePORTER application 3174896, RECEPTORS FOR IMMUNOGLOBULIN G ON LEUKOCYTES (5R01CA037155-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174896. Licensed CC0.

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