# THE CENTROSPHERE IN NORMAL AND TRANSFORMED CELLS

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 1988 · $56,022

## Abstract

The body's control over tissue cell migration appears to fail during
malignant invasion.  Since in these cases only the invading cells are
escaping the control, it seems likely that their own control systems of
cell migration are malfunctioning.  This proposal aims at the role of the
centrosphere in the control of tissue cell migration in vitro.  Using a new
method that allows for the first time to visualize reproducibly the
centrosphere in living, migrating cells the proposal intends to relate
movements of the centrosphere with movements of the entire normal and
virus-transformed cells.  In particular the timing of movements of the
centrosphere with respect to other time marks during reflattening after
mitosis, symmetrical migration of sister cells, cell-cell collision,
contact guidance, group migration and substrate-probing of the cells will
be examined, in order to determine the controlling events.  Traumatization
of the centrosphere by microirradiation and drugs will be related to
subsequent changes of motile behavior of the cells.  Changes in
microtubules radiating from the immunofluorescence.  Similar methods will
be aplied to determine the role of microfilaments and intermediate
filaments in the movement of the centrosphere.  The ability of multiple
centriole pairs to cooperate within the same cell will be tested by a
careful examination of the migration and the centrosphere in syncitia of
normal and transformed cultured cells.  (L)

## Key facts

- **NIH application ID:** 3175046
- **Project number:** 3R01CA037233-03S1
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **SAM.gov UEI:** KG76WYENL5K1
- **Principal Investigator:** GUENTHER W ALBRECHT-BUEHLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $56,022
- **Award type:** 3
- **Project period:** 1984-12-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175046

## Citation

> US National Institutes of Health, RePORTER application 3175046, THE CENTROSPHERE IN NORMAL AND TRANSFORMED CELLS (3R01CA037233-03S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175046. Licensed CC0.

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