# TUMOR TISSUES DURING HYPERTHERMIA AND HYPERGLYCEMIA

> **NIH NIH R01** · CARNEGIE-MELLON UNIVERSITY · 1990 · $169,641

## Abstract

The specific objective of this proposed study is to quantify the mechanisms
responsible for blood flow modification in normal and tumor tissues due to
hyperthermia and hyperglycemia.  Mature granulation tissue and VX2
carcinoma grown in a rabbit ear chamber preparation will be used as models
for normal and neoplastic tissues, respectively.  Using this preparation
and the microcirculation experimental setup in our laboratory,
modifications in blood flow in individual vessels following hyperthermia
and hyperglycemia have been determined.  In the proposed study, the role of
red and white blood cell rheology in this flow modification will be
determined.  A micropipette aspiration technique available in our
laboratory will be used to study cell deformability during hyperthermia and
hyperglycemia.  An intravital fluorescent microscopy technique will be used
to study cell adhesion to vessels.  This study will contribute to basic
pathophysiology of tumors and aid in improving present approaches to
hyperthermia treatment of tumors.

## Key facts

- **NIH application ID:** 3175065
- **Project number:** 5R01CA037239-05
- **Recipient organization:** CARNEGIE-MELLON UNIVERSITY
- **SAM.gov UEI:** U3NKNFLNQ613
- **Principal Investigator:** Rakesh K. Jain
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $169,641
- **Award type:** 5
- **Project period:** 1986-07-15 → 1991-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175065

## Citation

> US National Institutes of Health, RePORTER application 3175065, TUMOR TISSUES DURING HYPERTHERMIA AND HYPERGLYCEMIA (5R01CA037239-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175065. Licensed CC0.

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