# ONCOGENIC POTENTIAL OF THE HEPATITIS B-TYPE VIRUSES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1988 · $95,192

## Abstract

We are using the tools of oncogenetics and viral genetics to study
the molecular events that might be responsible for the well-
established relationship between chronic infection with hepatitis
B viruses and the appearance of primary hepatocellular
carcinoma.  In this application to continue an established
program, we emphasize two general approaches:

(1)  The behavior of wild-type and recombinant rodent
hepatitis B viruses is being examined in two natural hosts
for such viruses, the Eastern woodchuck and Beechey ground
squirrel, to identify viral and host determinants of host
range and pathogenicity.

(2)  A collection of PHCs from patients in Hong Kong is
being analyzed for rearrangements and aberrant expression
of known cellular proto-oncogenes and for insertional
activation of chromosomal domains that might harbor
previously unknown proto-oncogenes by hepatitis virus DNA.

## Key facts

- **NIH application ID:** 3175116
- **Project number:** 2R01CA037281-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** HAROLD E. VARMUS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $95,192
- **Award type:** 2
- **Project period:** 1984-03-01 → 1990-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175116

## Citation

> US National Institutes of Health, RePORTER application 3175116, ONCOGENIC POTENTIAL OF THE HEPATITIS B-TYPE VIRUSES (2R01CA037281-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175116. Licensed CC0.

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