# CYTOXIN METABOLITES & ANALOGS:  INTRACELLULAR CHEMISTRY

> **NIH NIH R01** · CATHOLIC UNIVERSITY OF AMERICA · 1987 · $86,045

## Abstract

Multinuclear Fourier-transform nuclear magnetic resonance spectroscopy will
be used in conjunction with a perfusable gel matrix to study the
intracellular chemistry of the cytoxan metabolites 4-hydroxy-cytoxan
(4-hydroxycyclophosphamide) aldophosphamide, and phosphoramide mustard.
The influence of metabolite structure and stereochemistry on the kinetics
of cellular uptake, intracellular detoxification, and intracellular
toxicogenation in normal versus neoplastic cells will be investigated using
metabolite-analogs.  These studies will probe those factors of cytoxan
metabolism which are pertinent to its oncostatic selectivity.

A series of novel lipophilic analogs of aldophosphamide will be synthesized
and tested for their anticancer activity against brain tumors.

## Key facts

- **NIH application ID:** 3175151
- **Project number:** 5R01CA037323-02
- **Recipient organization:** CATHOLIC UNIVERSITY OF AMERICA
- **SAM.gov UEI:** C31ES3WEAVQ5
- **Principal Investigator:** SUSAN M LUDEMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $86,045
- **Award type:** 5
- **Project period:** 1986-04-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175151

## Citation

> US National Institutes of Health, RePORTER application 3175151, CYTOXIN METABOLITES & ANALOGS:  INTRACELLULAR CHEMISTRY (5R01CA037323-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175151. Licensed CC0.

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