# SYNTHESIS OF THE AUREOLIC ACID ANTIBIOTICS FAMILY

> **NIH NIH R01** · HUNTER COLLEGE · 1988 · $127,264

## Abstract

A principal goal of this research is to achieve a total synthesis of a
member of the antitumor antibiotic family called the aureolic acids
illustrated below by olivomycin A.  A synthetic method that requires
development for this project is a glycosidation procedure that will permit
attachment of 2-deoxypyranose derivative to the antibiotic aglycone with
the requisite Beta-stereochemistry.  A further goal of this research is to
synthesize actinobolin and bactobolin, also antitumor antibiotics.  The
methods used have already been developed.  A third goal is to prepare the
antibiotic asperlin and the boronolides.

## Key facts

- **NIH application ID:** 3175204
- **Project number:** 5R01CA037359-05
- **Recipient organization:** HUNTER COLLEGE
- **SAM.gov UEI:** EK93EZLLBSC4
- **Principal Investigator:** RICHARD W. FRANCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $127,264
- **Award type:** 5
- **Project period:** 1983-12-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175204

## Citation

> US National Institutes of Health, RePORTER application 3175204, SYNTHESIS OF THE AUREOLIC ACID ANTIBIOTICS FAMILY (5R01CA037359-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175204. Licensed CC0.

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