# IMMUNOLOGICAL HETEROGENEITY OF CEA

> **NIH NIH R01** · CTR FOR MOLECULAR MEDICINE/IMMUNOLOGY · 1987 · $201,741

## Abstract

The general objective is to define the antigenic profile and immunochemical
characteristics of carcinoembryonic antigen (CEA) of the human digestive
system and to study the interrelationships of CEA, nonspecific
cross-reacting antigen (NCA), and two CEA-related meconium antigens.  Using
antibodies isolated from conventional antisera against unique and common
specificities on CEA, the immunochemical nature of CEA appearing in plasma
and tissue from normal individuals and patients with malignant and
nonmalignant gastrointestinal disease will be characterized according to
size and lectin binding properties.  The physicochemical, immunochemical,
and tissue specificity properties of the CEA-like meconium antigens will be
determined and compared to those of CEA and NCA. The interrelationships in
the expression of CEA and CEA-like antigens will be studied in plasma and
tissue specimens.  Murine monoclonal antibodies will be developed against
CEA obtained from colonic and gastric cancer as well as against the
CEA-like antigens to define further the antigenic specification of CEA and
related antigens.  A clearer definition of the immunochemical profile of
CEA and related antigens would allow a more complete understanding of their
interrelationships and provide opportunities to evaluate them with regard
to tissue specificity, response to therapy, patient survival, and cancer
cell evolution.  (2)

## Key facts

- **NIH application ID:** 3175275
- **Project number:** 5R01CA037411-04
- **Recipient organization:** CTR FOR MOLECULAR MEDICINE/IMMUNOLOGY
- **Principal Investigator:** DAVID V GOLD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $201,741
- **Award type:** 5
- **Project period:** 1983-09-01 → 1988-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175275

## Citation

> US National Institutes of Health, RePORTER application 3175275, IMMUNOLOGICAL HETEROGENEITY OF CEA (5R01CA037411-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175275. Licensed CC0.

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