# REPLICON CONTROL IN NORMAL AND TRANSFORMING CELLS

> **NIH NIH R01** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 1987 · $108,796

## Abstract

The interaction of parvovirus with its host cell is being used as a probe
of eukaryotic cell differentiation, DNA replication, and aging.  We will
explore the properties of parvovirus early and late promoters and the
interaction between them.  The early promoter produces a gene product that
positively regulates the late promoter.  The mechanisms and sequences
involved in this trans-activation will be studied.  The parvovirus early
promoter will be tested for dependence on a host cell regulatory protein
and cell lines suitable for cloning the gene for such a protein isolated.
In the terminal stages of fibroblast differentiation, the senescing cells
become resistant to parvovirus infection and these cells will be tested for
restriction of virus early promoter activity.

## Key facts

- **NIH application ID:** 3175318
- **Project number:** 5R01CA037481-03
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **SAM.gov UEI:** G15AG3BLLMH4
- **Principal Investigator:** SOLON L RHODE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $108,796
- **Award type:** 5
- **Project period:** 1985-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175318

## Citation

> US National Institutes of Health, RePORTER application 3175318, REPLICON CONTROL IN NORMAL AND TRANSFORMING CELLS (5R01CA037481-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175318. Licensed CC0.

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