# CONTROLLED RELEASE OF LIPOSOMAL CONTENTS IN MACROPHAGES

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1988 · $168,938

## Abstract

The objective of the proposed research is to investigate several
important factors which can influence the release of liposome-
associated materials (via encapsulation and/or covalent
conjugation) within macrophages.  The program is geared to
develop some novel methods of liposome formulation and to apply
the technique of gamma-ray perturbed angular correlation for
investigating the rate and extent of release of liposome-
associated materials within macrophages.  The focus is on
investigating the kinetic aspects of the release of liposome-
associated materials within macrophages, such that the results of
proposed basic study will lead to a rational approach to "fine
tune" the regimen of using activated tumoricidal macrophages for
combating cancer.

The goal of the proposed research will encompass the following
specific studies:

1.  How the lamellae of multilamellar liposomes affect the
macrophage-mediate release or (i) small, water soluble molecules
entrapped in liposomes and (ii) small molecules covalently bound
to the surface of liposomes;
2.  What the rate and extent of macrophage-mediate release of
liposome-associated materials from the "multivesicular"
liposomes are;
3.  The pharmacological effects of the "cytoplasmic" liposome-
associated muramyldi-peptide (MDP) on macrophage activation;
and
4.  The fate of liposomes which are in the cytoplasm of
macrophages.

## Key facts

- **NIH application ID:** 3175335
- **Project number:** 5R01CA037528-02
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** KARL J HWANG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $168,938
- **Award type:** 5
- **Project period:** 1986-12-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175335

## Citation

> US National Institutes of Health, RePORTER application 3175335, CONTROLLED RELEASE OF LIPOSOMAL CONTENTS IN MACROPHAGES (5R01CA037528-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175335. Licensed CC0.

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