# HIGH-SPEED ULTRASOUND IMAGING

> **NIH NIH R01** · DUKE UNIVERSITY · 1990 · $350,402

## Abstract

The long term goal of this proposal is to design, construct and clinically
evaluate a real time volumetric (3D) ultrasonic imaging system which is
also capable of visualizing and accurately representing blood flow in three
dimensions.  This instrument will permit the noninvasive assessment of
tumor and organ volumes as well as cardiac chamber volumes.  Such
measurements have the potential of improving decision on tumor treatment,
of assessing congenital and pathological states of various organs and of
evaluating cardiac function on a serial basis.  Incorporation of angle
independent 3D flow measurements will permit the rapid noninvasive
assessment of flow major peripheral vessels, deep abdominal vessels and
coronary arteries.  Flow imaging will also delineate the lumen of the
vessel thereby simplifying detection of atherosclerotic plaques.  The
specific aims of the proposal include the upgrading of the Duke Phased
Array Scanner to 256 transmit and receive channels and the development of
improved 2D arrays.  The proposed work is aimed at overcoming limitations
in sensitivity and dynamic range which currently preclude clinical use.
The upgraded system's performance will be assessed in terms of volumetric
determinations in vitro and in vivo tests.  The second major area of
proposed work is directed towards the development of ultrasonic blood
velocity measurement and imaging techniques which are suitable for
visualizing flow in 3D.  Two angle independent methods are to be studied.
Based on in vitro and in vivo studies, one of these will be selected as
most suitable for 3D flow imaging.  Hardware will be constructed to
implement this flow detection and measurement scheme.  In vivo studies are
proposed to validate the performance of the final system.

## Key facts

- **NIH application ID:** 3175369
- **Project number:** 2R01CA037586-10
- **Recipient organization:** DUKE UNIVERSITY
- **SAM.gov UEI:** TP7EK8DZV6N5
- **Principal Investigator:** OLAF T VON RAMM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $350,402
- **Award type:** 2
- **Project period:** 1981-07-01 → 1994-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175369

## Citation

> US National Institutes of Health, RePORTER application 3175369, HIGH-SPEED ULTRASOUND IMAGING (2R01CA037586-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175369. Licensed CC0.

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