# PROSTATIC ANDROGEN RECEPTORS--FORM AND FUNCTION

> **NIH NIH R01** · AUGUSTA UNIVERSITY · 1987 · $92,845

## Abstract

These studies are designed to examine the significance within prostatic
tissue of androgen receptor species which, by virtue of differences in
their avidity for androgenic ligands, may function as regulators of the
responsiveness of androgen-sensitive cells.  In pursuit of our observation
that two such cytoplasmic forms of this receptor do co-exist, we propose to
define various physicochemical properties of these forms, as well as any
others which may occur, including especially nuclear and heat-transformed
cytoplasmic moieties.  The emphasis will be on comparative aspects of
interaction with androgens, and susceptibility to interconversion by a
cytoplasmic factor which has been discovered and which will be purified and
characterized further.  The relative levels of the different receptor forms
will be assessed under a variety of experimentally-induced changes in
endogenous hormonal milieu, including castration-replacement, aging, and
administration of assorted types of steroid hormones and prolactin.  We
will exploit the ability to separate the cytoplasmic receptor forms by
ammonium sulfate fractionation in experiments wherein the dynamics of
nuclear uptake and mechanisms of nuclear retention of receptor will be
explored.  Patterned induction of specific protein synthesis in response to
androgen will be investigated as a function of the relative
receptor-dictated responsiveness of the cells; these analyses are an
outgrowth of preliminary observations which suggest a potentially important
correlation.  While not within the scope of this initial stage of the
project, the implications of these studies with respect to defining a
relationship between functional androgen receptor concentration and
prediction of responsiveness of human prostatic cancer to endocrine therapy
will certainly constitute the next major phase of this work.

## Key facts

- **NIH application ID:** 3175395
- **Project number:** 5R01CA037614-02
- **Recipient organization:** AUGUSTA UNIVERSITY
- **SAM.gov UEI:** N4WWJC8T2593
- **Principal Investigator:** THOMAS G. MULDOON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $92,845
- **Award type:** 5
- **Project period:** 1986-07-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175395

## Citation

> US National Institutes of Health, RePORTER application 3175395, PROSTATIC ANDROGEN RECEPTORS--FORM AND FUNCTION (5R01CA037614-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175395. Licensed CC0.

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