# BIOMOLECULES & ANALOGUES AS ANTIVIRAL/ANTITUMOR AGENTS

> **NIH NIH R01** · WAYNE STATE UNIVERSITY · 1991 · $124,754

## Abstract

The thrust of the program is the synthesis of compounds which are
known or have potential as antitumor/antiviral agents with
appropriate followup biological screening.  The overall objectives
are:

(i)  Development of efficient methods for the synthesis of several
unusual, naturally occurring nucleosides analogues which have
antitumor and/or antiviral activity.

(ii)  Synthesis and screening of novel nucleoside analogues
designed as possible antitumor/antiviral agents by analogy with
known bioactive substances or on the basis of known or probable
enzymatic pathways.

(iii)  Synthesis and screening for antitumor activity of a variety of
analogues of prostanoids and prostanoids metabolites.

(iv)  Development of efficient methods for the production of
optically pure starting materials, particularly
dialkoxycyclopentenones, which should be widely useful in
enantiospecific syntheses of a variety of bioactive substances.

(v)  Development of new synthetic methods of general interest for
organic synthesis.

(vi)  Further demonstration of the applicability of the materials
and methods developed by synthesis of a selection of additional
targets of biological interest.

Targets of priority include carbocylic nucleoside analogues based
on the carbocycle of neplanocin A, novel nucleosides designed to
be inhibitors of methyltransferases, novel variations of the chain
terminator nucleosides drugs azidothymidine and dideoxycytodine
of current interest in AIDS therapy, the recently discovered
antiviral nucleoside oxetanocin and a variety of electrophilic
cyclopentenones related to prostanoids and designed to serve as
DNA polymerase inhibitors.

## Key facts

- **NIH application ID:** 3175658
- **Project number:** 5R01CA037806-07
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **SAM.gov UEI:** M6K6NTJ2MNE5
- **Principal Investigator:** CARL RANDOLPH JOHNSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $124,754
- **Award type:** 5
- **Project period:** 1985-05-01 → 1993-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175658

## Citation

> US National Institutes of Health, RePORTER application 3175658, BIOMOLECULES & ANALOGUES AS ANTIVIRAL/ANTITUMOR AGENTS (5R01CA037806-07). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3175658. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*