# FUNCTIONAL ANALYSIS OF NONSPECIFIC T CELL SUPPRESSION

> **NIH NIH R01** · SAINT LOUIS UNIVERSITY · 1987 · $107,201

## Abstract

Our overall objectives are to characterize and study the mode of action of
regulatory factors produced by nonantigen specific T suppressor cells.
These T cells, which show no apparent antigen specificity, have been found
in a variety of diseases and can most easily be generated for study in
vitro by exposure to the mitogen Concanavalin A.  A major drawback to
elucidating the nature of their suppression, however, is the heterogeneity
of cells resulting from mitogen activation.

We intend to utilize hybridomas produced from these T cells to examine
their suppressive activity in well-defined systems measuring T-\and B-cell
activation.  The physicochemical nature of isolated factors and binding
specificity for cell surface determinants will be examined.  We shall ask
whether distinct factors inhibit the secretion of defined lymphokines (B
cell signals) from cloned functional T helper cells or inhibit T cells at a
particular point in the cell cycle during activation.  In particular, we
shall determine whether additional molecules inhibit specific B-cell
subpopulations at either stages of proliferation or differentiation and
whether inhibition is dependent on the nature of the triggering signal to
the B cell.  (SR)

## Key facts

- **NIH application ID:** 3175701
- **Project number:** 5R01CA037834-03
- **Recipient organization:** SAINT LOUIS UNIVERSITY
- **SAM.gov UEI:** JNBLLTBTLLD8
- **Principal Investigator:** JAMES E SWIERKOSZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $107,201
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175701

## Citation

> US National Institutes of Health, RePORTER application 3175701, FUNCTIONAL ANALYSIS OF NONSPECIFIC T CELL SUPPRESSION (5R01CA037834-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175701. Licensed CC0.

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