# MONOCLONAL ANTIBODIES/SMALL CELL CARCINOMA OF THE LUNG

> **NIH NIH R01** · DARTMOUTH COLLEGE · 1989 · $181,256

## Abstract

This project is designed to explore the diagnostic and therapeutic
potential of a panel of monoclonal antibodies (MoAbs) that react
with SCCL-associated or specific cell surface antigens.  The
majority of the MoAbs were prepared in this laboratory during the
first years of this on-going study (now in its 4th year) and in
addition, we have acquired two SCCL-reactive MoAbs, TFS-2 and TFS-
4 that augment our ability to carry out the studies we propose.
In particular, we will undertake a prospective evaluation of SCCL
tumor immunophenotyping for the purpose of establishing meaningful
clinical correlations.  All patients with lung cancer seen at the
DHMC will have their tumor cells examined by immunohistochemistry
for the expression of antigens defined by a battery of MoAbs.  The
tumor registry of DHMC will collect the clinical data thus
permitting data analyses and correlations.  A second project will
be the development of a sensitive test for the detection of small
numbers of SCCL cells in other cell populations, such as bone
marrow.  This will involve the use of multiparameter flow cytometry
to measure simultaneously DNA content and surface expression of
SCCL 175.  This technique will be used to establish the incidence
of bone marrow metastases and to monitor the efficacy of SCCL
purging of bone marrow for autologous bone marrow transplantation
(ABMT).  Another project will examine the potential of MoAbs to
remove SCCL cells from bone marrow using immunomagnetic beads.  We
will explore the use of several MoAbs conjugated to magnetic
microspheres for their abilities, alone and in combination, to
prepare marrow from SCCL patients tumor-free for ABMT.  Finally,
we will prepare hetero-antibodies (HA) of anti-SCCL MoAbs and MoAbs
to cytotoxic effector cells.  These HA will be examined for their
abilities to mediate SCCL killing.  We expect these pre-clinical
studies to lead immediately to clinical applications for the
diagnosis and treatment of patients.

## Key facts

- **NIH application ID:** 3175751
- **Project number:** 2R01CA037868-05
- **Recipient organization:** DARTMOUTH COLLEGE
- **SAM.gov UEI:** EB8ASJBCFER9
- **Principal Investigator:** EDWARD David BALL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $181,256
- **Award type:** 2
- **Project period:** 1985-09-30 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175751

## Citation

> US National Institutes of Health, RePORTER application 3175751, MONOCLONAL ANTIBODIES/SMALL CELL CARCINOMA OF THE LUNG (2R01CA037868-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175751. Licensed CC0.

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