# MONOCLONAL ANITBODIES TO SMALL CEL CARINOMA OF THE

> **NIH NIH R01** · DARTMOUTH COLLEGE · 1987 · $152,420

## Abstract

The proposed research is directed toward the continued development of a
panel of monoclonal antibodies with specificity for antigens expressed on
tumor cells of small cell carcinoma of the lung (SCCL).  We have already
produced four potentially useful monoclonal antibodies (MoAbs) that are
relatively specific for SCCL.  These four MoAbs, along with other murine
and human MoAbs that we propose to develop, will be utilized to study the
immunobiology of SCCL cells and thus to develop the basis for potentiation
immunotherapy of this disease in an autologous bone marrow transplantation
program.  Freshly isolated tumor cells from patients with SCCL and cell
lines available at the Dartmouth Medical School will be used in a variety
of in vitro studies as well as for the production of additional
hybridomas.  Reactivities with freshly isolated SCCL tissue as well as cell
lines will be assessed by cytofluorography and by complement-dependent
cytotoxicity.  Cell surface antigens characteristic of SCCL cells will be
purified, partially characterized and used for the preparation of a second
generation of anti-SCCL MoAbs.  Heterogeneity of antigen expression in SCCL
within and among individual cell populations from patients, and SCCL cell
lines and clones of SCCL cell lines will be evaluated by cytofluorography.
Assays for detection of SCCL-associated antigens in body fluids of patients
will be developed and used to correlate antigen expression by cell lines
and in the serum of patients with SCCL with disease parameters.  MoAb
induced modulation of cell surface antigens or tumor cell selection will be
evaluated as possible tumor cell escape mechanisms.  Attempts will be made
to develop a panel of MoAbs that is capable of abrogating tumor cell
escape.  Overall, these studies represent a comprehensive approach to an
evaluation of the potential utility of MoAbs in the diagnosis and therapy
of SCCL and in basic studies of SCCL cell biology.

## Key facts

- **NIH application ID:** 3175752
- **Project number:** 5R01CA037868-03
- **Recipient organization:** DARTMOUTH COLLEGE
- **SAM.gov UEI:** EB8ASJBCFER9
- **Principal Investigator:** EDWARD David BALL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $152,420
- **Award type:** 5
- **Project period:** 1985-09-30 → 1989-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175752

## Citation

> US National Institutes of Health, RePORTER application 3175752, MONOCLONAL ANITBODIES TO SMALL CEL CARINOMA OF THE (5R01CA037868-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175752. Licensed CC0.

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