# DIAGNOSTIC RADIOLOGY-IMAGING-METABOLISM OF TUMOR

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1992 · $208,593

## Abstract

The overall goal of our animal studies is to evaluate how various in
vitro functional and morphological parameters compare with MRI/31p-MMR
and PET data of brain tumor growth and response to steroid therapy. PET
data will include blood flow, oxygen  consumptionand
18F-2-Fluoro-2-deoxyglucose uptake. The studies are designed to
quantitate data using in vivo MRI/MRS and PET techniques as well as
established in vitro assay procedures. In the canine work, MRI and PET
studies will be performed on the same animals using localization
techniques that will provide examination of the same tissue sample
volume. The results of both non invasive in vivo procedures will be
correlated to in vitro detailed morphometric-histological analysis of the
tumors as well as brain/ tumor tissue specific gravity measurements and
blood flow determinations using microsphere techniques. High resolution
(microscopy) imaging procedures will be employed to study rabbit brain
tumors as a function of their growth and response to therapy aimed at
reducing tumor induced edema. The MRI high resolution images will be
compared to detailed histological evaluation of the sample volume area.
Tumor associated edema will be quantitated using measurements of Tl and
T2 relaxation times and compared to direct in vitro measurements of tumor
and edematous brain tissue water content extravasation of plasma proteins
and vascular - extravascular space compartment determinations. The
proposed studies address timely and important issues relating to the
information provided and the potential clinical applications of MRI/MRS
and PET.

## Key facts

- **NIH application ID:** 3175767
- **Project number:** 5R01CA037870-07
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** JAMES H ANDERSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $208,593
- **Award type:** 5
- **Project period:** 1984-07-01 → 1993-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175767

## Citation

> US National Institutes of Health, RePORTER application 3175767, DIAGNOSTIC RADIOLOGY-IMAGING-METABOLISM OF TUMOR (5R01CA037870-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175767. Licensed CC0.

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