# MALIGNANT POTENTIAL OF THE COMPONENTS OF WILMS' TUMORS

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 1988 · $90,687

## Abstract

The long-term objective of the proposed research is to continue
the formation of a model system for cancer research based on the
culture of Wilms' tumor.  Due to the inherent properties of this
tumor type, this system will provide a superior model system to
assign the genetic events that lead to tumorigenesis, tumor
progression and tumor differentiation.  The specific aims center
on continuing to improve the cell culture conditions for the
growth of the blastemal elements from both Wilms' tumors and
normal fetal kidneys, the growth of the anaplastic variant, and
other commonly occurring elements of Wilms' tumors.  The second
goal will be to define the conditions under which the blastemal
component from both Wilms' tumors and fetal kidneys undergoes
the differentiation process in culture and in vivo.  Monoclonal
antibodies to the blastemal elements will be generated to help
define the changes which occur when the blastemal element
undergoes differentiation into mature tubule, glomerular, and
stromal elements.  Studies are also proposed to develop conditions
by which the anaplastic variant of Wilms' tumor can be selected
from classical Wilms' tumors composed primarily of a blastemal
element.  Lastly, studies will be initiated to define the production
and genetic regulation of insulin-like growth factor II in the
cultured elements from Wilms' tumors as well as the blastemal
element of normal kidneys.  The completion of these studies will
characterize a model system for cancer research and also provide
fundamental knowledge regarding the pathogenesis of Wilms's
tumors.

## Key facts

- **NIH application ID:** 3175815
- **Project number:** 5R01CA037887-05
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **SAM.gov UEI:** NHV3GTWSALA7
- **Principal Investigator:** ABBOTT J GARVIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $90,687
- **Award type:** 5
- **Project period:** 1987-07-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175815

## Citation

> US National Institutes of Health, RePORTER application 3175815, MALIGNANT POTENTIAL OF THE COMPONENTS OF WILMS' TUMORS (5R01CA037887-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175815. Licensed CC0.

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