# MALIGNANT POTENTIAL OF THE COMPONENTS OF WILMS TUMORS

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 1992 · $232,678

## Abstract

The long-term goal of the proposed research is the formation of a human
cancer model system based on the childhood cancer, Wilms' tumor.  The
initial goal of the proposed research is to continue the development of
cell lines representative of the various components comprising this
tumor, especially the malignant blastemal element.  Related to this goal,
is the continued development and maintenance of tumor heterotransplants
grown in nude mice.  Together, these systems provide a readily available
source of tissues and cells for the study of Wilms' tumor cell biology,
both for the applicant and the scientific community.  Using serum-free
cell culture techniques, it is also planned to establish the culture
conditions for the maintenance of the renal blastemal element from the
normal fetal kidney for use in comparative studies with its malignant
counterpart.  The second goal of this research is the continued
production and characterization of monoclonal antibodies to the blastemal
element of Wilms' tumor and normal kidney.  This is performed using
standard hybridoma cell fusion techniques and histochemical
characterization.  The production and characterization of these
monoclonal antibodies provides the first comprehensive panel of reagents
to characterize the developing fetal kidney and its neoplasms.  Lastly,
studies are proposed to continue to define the role of growth factors in
Wilms' tumors.  Specifically, studies are proposed to define the role of
IGF-2, N-myc, c-myc and PDGF in the growth and differentiation of normal
and Wilms' tumor tissues and cell lines.  Completion of the studies
proposed would provide a valuable model system for the study of human
cancer.

## Key facts

- **NIH application ID:** 3175817
- **Project number:** 5R01CA037887-08
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **SAM.gov UEI:** NHV3GTWSALA7
- **Principal Investigator:** ABBOTT J GARVIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $232,678
- **Award type:** 5
- **Project period:** 1987-07-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175817

## Citation

> US National Institutes of Health, RePORTER application 3175817, MALIGNANT POTENTIAL OF THE COMPONENTS OF WILMS TUMORS (5R01CA037887-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175817. Licensed CC0.

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