# CYCLO-OXYGENASE PRODUCTS AND MAMMARY CANCER

> **NIH NIH R01** · BARBARA ANN KARMANOS CANCER INSTITUTE · 1987 · $109,683

## Abstract

The long-term objective of this research is to study the role of
cyclooxygenase products of arachidonic acid metabolism in tumor growth and
metastasis.  The specific aims are:  (1) to determine the effects of
cyclooxygenase inhibitors on the growth and metastasis of murine mammary
adenocarcinomas and (2) to define the interactions between tumor-associated
cyclooxygenase products and antitumor immune effector functions.  We have
now shown that cyclooxygenase inhibitors reduce the spontaneous metastasis
of these tumors and that this effect may be mediated by increasing the
susceptibility of these tumor cells to killing by both macrophage and
natural cytotoxic effector cells.

These studies will focus on determining the effects of cyclooxygenase
inhibitors on the nature of host infiltrates within tumors and evaluating
the effect these inhibitors have on immune effector cells.  Defining the
role of these naturally-occurring products in tumor growth and
understanding how these products affect immune function will provide a
rational basis for designing immunotherapeutic agents.  (HF)

## Key facts

- **NIH application ID:** 3175899
- **Project number:** 5R01CA037943-03
- **Recipient organization:** BARBARA ANN KARMANOS CANCER INSTITUTE
- **SAM.gov UEI:** NAJZPZ4GN5B3
- **Principal Investigator:** Amy M. Fulton
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $109,683
- **Award type:** 5
- **Project period:** 1984-07-01 → 1988-02-04

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175899

## Citation

> US National Institutes of Health, RePORTER application 3175899, CYCLO-OXYGENASE PRODUCTS AND MAMMARY CANCER (5R01CA037943-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175899. Licensed CC0.

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