# BREAST CANCER DIAGNOSIS BY LIGHT SCANNING

> **NIH NIH R01** · UNIVERSITY OF CINCINNATI · 1988 · $321,367

## Abstract

This proposal is a blinded, prospective, multi-institutional, phase 2
evaluation of differential light transmission scanning (diaphanography,
transillumination, or spectroscopy).  The study is designed to determine:
1) specificity and sensitivity by stage and size of breast cancer detected
in a symptomatic, referred population; 2) transferability of the
technology; and 3) relationship of the independent contributions for
detection of blinded clinical examination, blinded mammography and blinded
spectroscopy interpretations.  After adequate training and testing of all
participants has been achieved, all observers will participate in a
round-robin reading of all cases collected at each institution.  The data
base, including all follow up data, will be maintained at the University of
Cincinnati Medical Center Computer Center.  No correlative information will
be released to the participating investigators until the conclusion of the
study.  From these data, the supplementary or complementary role of
Spectrascanning in the diagnostic evaluation of patients with suspected
breast cancer should be possible.  If the test shows promise in detecting
minimal breast cancers, further evaluation of the modality as a screening
tool will be feasible.  The imaging equipment is currently available at
each institution.  It will be necessary to examine at least 6000 patients
for this study to accrue sufficient stage 1 and stage 2 cancers, and
provide a reasonable sampling of minimal breast cancers.  This will cost
$49.00 per person examined exclusive of indirect costs.  If the modality
can replace or reduce the reliance on ionizing radiation for earlier
detection, the potential health benefits are obvious.  Further, by defining
the limitations and benefits of the method, more appropriate and cost
effective clinical use can be made of it.

## Key facts

- **NIH application ID:** 3175963
- **Project number:** 5R01CA037970-04
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **SAM.gov UEI:** DZ4YCZ3QSPR5
- **Principal Investigator:** MYRON MOSKOWITZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $321,367
- **Award type:** 5
- **Project period:** 1985-09-01 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175963

## Citation

> US National Institutes of Health, RePORTER application 3175963, BREAST CANCER DIAGNOSIS BY LIGHT SCANNING (5R01CA037970-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175963. Licensed CC0.

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