# IDIOTYPE-ANTI-IDIOTYPE MODULATION OF IMMUNITY TO M-MULV

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1992 · $159,696

## Abstract

Tumors and infectious diseases are among the more important problems facing
surgeons.  This proposal is designed to evaluate mechanisms by which
monoclonal antibodies may modulate host defense against retrovirus induced
tumors and may have implications for other surgically important problems
such as pre- and post operative infection, transplantation and other
retrovisus induced diseases.

Two major approaches are taken (1) monoclonal antibodies may function
immunotherapeutically and (2) idiotype regulation can be a major factor to
Ii influence immunity to tumors and/or infection. We propose that (1)
monoclonal antibodies (AB1) with specificity for retrovirus induced tumor
antigens can effectively inhibit tumor growth, (2) they can induce
anti-idiotypic (Ab2) and anti-anti-idiotypic (Ab3) responses a component of
which (Ab1) binds antigen, and (3) further that monoclonal anti-idiotypic
antibody (Ab2) can be used as a vaccine in the absence of antigen to
preimmunize against tumor growth, but (4) may induce tumor enhancement if
administered following tumor induction, and (5) that Ab1 or Ab2 may alter
immunologic memory. The experiments proposed to test this hypothesis will
be conducted with the Moloney leukemia virus (M-MuLV) and Moloney Sarcoma
virus (M-MuSV) induced tumors in BALB/c mice. Our previous experiments have
indicated a promising feasibility of these studies which may have relevance
to other surgically important diseases in addition to tumors.

## Key facts

- **NIH application ID:** 3175995
- **Project number:** 5R01CA038008-06
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** John Franklin Kearney
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $159,696
- **Award type:** 5
- **Project period:** 1987-08-19 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175995

## Citation

> US National Institutes of Health, RePORTER application 3175995, IDIOTYPE-ANTI-IDIOTYPE MODULATION OF IMMUNITY TO M-MULV (5R01CA038008-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175995. Licensed CC0.

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