# MONOCLONAL ANTIBODIES TO MELANOMA-ASSOCIATED ANTIGENS

> **NIH NIH R01** · ONCOGEN · 1988 · $205,967

## Abstract

We plan to continue our monoclonal antibody studies on human melanomas
towards the development of pre-clinical immunotherapeutical procedures for
melanoma.  There are 4 Specific Aims:

1.  To continue our characterization of cell surface antigens of human
melanomas by using monoclonal mouse antibodies.  Our major effort will go
into obtaining antibodies to antigens expressed by (malignant) melanoma but
not by (benign) nevi.  As part of this project, we shall look for
antibodies distinguishing the two major subtypes of melanoma (nodular,
superficial spreading) and - to the extent logistically possible - for
antibodies distinguishing primary and metastatic melanoma.  We shall also
investigate the extent to which various melanoma-associated antigens (p97,
a proteoglycan, a GD3 ganglioside, as well as the "new" antigens identified
under Aim #1) are expressed in cells from human fetuses.

2.  To obtain anti-idiotypic antibodies to human melanomas by using
monoclonal mouse antibodies as immunogens and to use these antibodies to
probe the immunological repertoire of melanoma patients; under Aim #4 the
antibodies will also be used as immunogens in mice.

3.  To test the ability of anti-melanoma antibodies to destroy human
melanomas xenografted to nude mice.  The effect of antibody alone, and
antobody combined with an immunomodulator (e.g., BCG or C-parvum) will be
investigated as part of this.

4.  To use a model, in which the genes for p97 or the proteoglycan antigen
are inserted into mouse tumor cells, to study anti-tumor effects, first, of
passive immunization with anti-p97 antibody and, second, of active
immunization with cells, antigens or anti-idiotypic antibodies.

## Key facts

- **NIH application ID:** 3175999
- **Project number:** 5R01CA038011-05
- **Recipient organization:** ONCOGEN
- **Principal Investigator:** INGEGERD E HELLSTROM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $205,967
- **Award type:** 5
- **Project period:** 1984-08-01 → 1989-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3175999

## Citation

> US National Institutes of Health, RePORTER application 3175999, MONOCLONAL ANTIBODIES TO MELANOMA-ASSOCIATED ANTIGENS (5R01CA038011-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3175999. Licensed CC0.

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