# MAINTENANCE OF THE BLOOM'S SYNDROME REGISTRY

> **NIH NIH R01** · NEW YORK BLOOD CENTER · 1988 · $38,127

## Abstract

The Bloom's Syndrome Registry is comprised of most of the bona fide cases
of Bloom's syndrome (BS) that have been recognized since 1954, when the
condition first was described.  The Registry was developed, and its
maintenance in the coming years is proposed, primarily because of one
particular clinical feature of the syndrome, to wit, cancer proneness.  The
Registry has become a vehicle for the surveillance of the world's BS
population with respect to the incidence, age of onset, and distribution of
types of neoplasia, in both affected homozygotes and in heterozygotes
(carriers of the BS gene, who appear phenotypically normal).  Already the
data suggest that of the known recessively-transmitted genetic disorders
that predispose to cancer BS does so most strongly.  Furthermore, the
distribution of types of cancers may be similar to that in the general
population.  Simultaneously, information on the natural course of BS
(interesting in several ways) is being accumulated.  Also, the family
contacts provide a source of specimens, such as blood cells, tissue culture
cell lines, and tumor DNA for use in other studies.

In one respect, then, the Registry, in being a central repository for
information on a affected families throughout the world, may be viewed as a
research resource.  Support is requested not for a research project in the
usual sense but for maintenance of the Bloom's Syndrome Registry itself,
i.e., to monitor a cancer-prone population, one that is small but unusually
interesting for several disciplines (e.g., oncology, immunology,
cytogenetics, and DNA metabolism).

## Key facts

- **NIH application ID:** 3176036
- **Project number:** 5R01CA038036-05
- **Recipient organization:** NEW YORK BLOOD CENTER
- **SAM.gov UEI:** LXCNYLGGX6N7
- **Principal Investigator:** JAMES L GERMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $38,127
- **Award type:** 5
- **Project period:** 1984-07-01 → 1989-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176036

## Citation

> US National Institutes of Health, RePORTER application 3176036, MAINTENANCE OF THE BLOOM'S SYNDROME REGISTRY (5R01CA038036-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176036. Licensed CC0.

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