# BIOLOGICAL STUDIES OF HUMAN INTERLEUKIN 1

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1989 · $151,325

## Abstract

The specific aims of this proposal are:

1) To determine if liposomes containing Interleukin 1 on their
outer membranes may be used as synthetic macrophages to
present antigen to lymphocytes, initiate the lymphokine cascade,
kill IL 1-sensitive tumor cells, and stimulate the growth of IL 1-
responsive cells.

2) To evaluate the biological activity of IL 1-liposomes in vivo for
the ability to initiate the sequelae of inflammation, to induce
angiogenesis, and to inhibit the growth and metastasis of tumors.

3) To elucidate the molecular mechanisms of macrophage
activation which lead to induction and translation of IL 1-specific
mRNA and to evaluate the effects of specific inhibitors of
macrophage activation.

4) To determine the series of post-translational intracellular
events which lead to the secretion of IL 1 from the monocyte and
the deposition and anchoring of IL 1 in the membrane.

5) To further evaluate synthetic peptides which have been
demonstrated to inhibit the biological activity of human IL 1.

## Key facts

- **NIH application ID:** 3176053
- **Project number:** 5R01CA038043-06
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **SAM.gov UEI:** S3GMKS8ELA16
- **Principal Investigator:** Lawrence B Lachman
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $151,325
- **Award type:** 5
- **Project period:** 1984-07-01 → 1992-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176053

## Citation

> US National Institutes of Health, RePORTER application 3176053, BIOLOGICAL STUDIES OF HUMAN INTERLEUKIN 1 (5R01CA038043-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176053. Licensed CC0.

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