# RESIDUAL RADIATION DAMAGE IN NORMAL TISSUES

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1987 · $103,212

## Abstract

The general objective of the proposed research is to measure the extent and
rate of decay of remembered dose in four normal tissues that express their
injury at different times after irradiation and for the late fibrotic
response in three of the tissues.  More specifically, these studies will
focus on the acute response in skin and intestine, the late response in
lung and kidney, and the later appearing damage in bowel (stenosis), lung
(fibrosis), and skin (contraction).  The investigations will be carried ut
in mice using well established radiobiological techniques.  These studies
should increase our understanding of the kinetics of depletion and
repopulation of the target cells for acutely and late responding normal
tissues and for the later fibrotic wave of damage common to all irradiated
normal tissues, as well as provide insight into fundamental processes of
tissue response to injury.  The potential importance of these studies to
clinical radiotherapy is that they should provide radiotherapists with
guidelines for designing treatment protocols when retreatment of a
previously irradiated site is necessary.

## Key facts

- **NIH application ID:** 3176127
- **Project number:** 5R01CA038106-03
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **SAM.gov UEI:** S3GMKS8ELA16
- **Principal Investigator:** ELIZABETH L TRAVIS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $103,212
- **Award type:** 5
- **Project period:** 1984-08-01 → 1988-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176127

## Citation

> US National Institutes of Health, RePORTER application 3176127, RESIDUAL RADIATION DAMAGE IN NORMAL TISSUES (5R01CA038106-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176127. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*