# RESIDUAL RADIATION DAMAGE IN NORMAL TISSUES

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1990 · $129,894

## Abstract

The goal of this research is to understand in greater detail the
mechanisms involved in the responses of normal tissues to
radiation.  The rationale for these studies is based on the current
controversy in normal tissue radiobiology concerning the
pathogenesis of damage in "late" responding normal tissues, i.e.,
parenchyma vs. stroma, and the distinction between "late"
responding normal tissues and chronic tissue damage.  The
capacity of irradiated tissues to recover over a period of months
to years after initial exposure (as assessed by the amount of
residual damage) will be determined with the expectation that
late responding normal tissues will recover later and over a longer
period of time than acute responding normal tissues, reflecting
depletion of a critical cell specific for the response whereas the
recovery pattern for chronic tissue damage may be similar for all
tissues reflecting a common cellular etiology.  Once the recovery
profiles have been defined, other studies will investigate the
mechanisms underlying any observed changes in retreatment
tolerance.  The proposed work is divided into three specific aims.
The first proposes to determine the recovery pattern for late
responding normal tissues and for chronic responses.  More
specifically, these studies will focus on two late responding
normal tissues, kidney and lung, and chronic damage in bowel,
skin, and lung.  Aim 2 will then investigate the mechanisms
underlying any observed changes in retreatment response in
previously irradiated tissues.  These studies will involve
determining oxygen-enhancement ratios for previously irradiated
tissues as well as to determine if, when, and in what cell
proliferation occurs.  Aim 3 will investigate the repair capacity of
previously irradiated tissues when recovery is complete or during
stimulated proliferation.  These studies should increase our
understanding of the kinetics of depletion and repopulation of the
target cells for late responding normal tissues and for the chronic
wave of damage common to all irradiated tissues as well as to
provide insight into fundamental processes involved in tissue
injury and repair.  The potential importance of these studies to
clinical radiotherapy is that they should provide radiotherapists
with quantitative data and guidelines for designing treatment
protocols when retreatment of a previously irradiated site is
necessary.

## Key facts

- **NIH application ID:** 3176129
- **Project number:** 5R01CA038106-06
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **SAM.gov UEI:** S3GMKS8ELA16
- **Principal Investigator:** ELIZABETH L TRAVIS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $129,894
- **Award type:** 5
- **Project period:** 1984-08-01 → 1993-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176129

## Citation

> US National Institutes of Health, RePORTER application 3176129, RESIDUAL RADIATION DAMAGE IN NORMAL TISSUES (5R01CA038106-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176129. Licensed CC0.

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