# MODULATION OF CARCINOGENESIS BY MONOTERPENOIDS

> **NIH NIH R01** · UNIVERSITY OF WISCONSIN-MADISON · 1993 · $183,879

## Abstract

The research proposed here seeks to define the efficacy of the use of
orange peel oil as an anticarcinogen while further defining its mechanism
of action in this role.  To accomplish this HPLC techniques will be used to
isolate the components of orange peel oil.  The anticarcinogenic potency of
these components will be quantitated by feeding them in a totally defined
diet to rats exposed to DMBA.  Carcinogen specificity will be defined by
testing the ability of the orange peel oil anticarcinogen(s) to inhibit
both spontaneous and induced mammary tumors.  Organ specificity will be
examined by testing the ability of the orange peel oil anticarcinogen(s) to
inhibit neoplastic changes in mammary gland, skin and bladder.  Species
specificity studies will compare the response of carcinogen exposed rats
and mice to orange oil anticarcinogens.  In addition, similar in vitro
comparisons will be made using rat and human primary parenchymal cells from
mammary gland and liver.  Individual specificity will be modeled with rat
strains possessing high or low sensitivity to the induction of mammary
carcinomas.  All animal experiments will be analyzed using both parametric
and nonparametric statistical procedures.  Once the anticarcinogen is
identified its pharmacokinetics and metabolism will be defined.  The
biological activity of these metabolites will be determined.  The
mechanism(s) of action of the orange peel oil anticarcinogen(s) and/or its
metabolites will be studied.

## Key facts

- **NIH application ID:** 3176167
- **Project number:** 5R01CA038128-08
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **SAM.gov UEI:** LCLSJAGTNZQ7
- **Principal Investigator:** MICHAEL N GOULD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $183,879
- **Award type:** 5
- **Project period:** 1984-07-01 → 1995-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176167

## Citation

> US National Institutes of Health, RePORTER application 3176167, MODULATION OF CARCINOGENESIS BY MONOTERPENOIDS (5R01CA038128-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176167. Licensed CC0.

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