# LIPID DIET EFFECTS ON COLON TUMOR GROWTH AND METASTASES

> **NIH NIH R01** · BOSTON UNIVERSITY MEDICAL CAMPUS · 1989 · $167,596

## Abstract

The long term objectives of this laboratory are to identify
nutritional factors which contribute to, or could reduce, the high
incidence of colon cancer in western cultures.  Hypothesis:  in
BALB/c mice the growth of colon tumor CT-26 when implanted into the
colon, a nutrition responsive site (NR), is enhanced by increasing
dietary essential fatty acids (EFA).  These effects are mediated
via the cyclooxygenase pathway in the synthesis of prostaglandin
(PG's) of the 1 and 2 series.  Inhibition of tumor growth in the
colon and of pulmonary colonization is related to inhibition of
arachidonic acid metabolism in the cyclooxygenase pathway by the
constituents of dietary marine oils, eicosopentaenoic acid (EPA)
and docosahexaenoic acid (DHA), which are utilized for PG's of the
3 series.  These events, if indeed nutrition related, are less
likely to occur when CT-26 is implanted in the mid scapula area,
a nutrition non responsive site (NNR).  Using CT-26 tumors
implanted in colon (NR), and in mild scapula (NNR), various
isocaloric nutritional lipid intervention are planned, including
varying EFA with and without varying marine oils.  Corollary
studies are conducted in tissue culture with CT-26 cells.
Nutritional interventions will be evaluated on tumor latency time,
tumor growth, pulmonary colonization, metastatic potential, and the
demise of the host.  Effects of EFA, EPA, and indomethacin on
prostaglandin synthesis and lipid profiles of tumors and tissues
is assessed.  These studies should provide:  1) an understanding
of the relationship of EFA's to tumor growth and metastasis, 2)
insights on the relationship of EPA and DHA inhibition of colon
tumors, 3) data on the feasibility of mixtures of marine oil with
other dietary lipids as colon tumor inhibitors, 4) guidelines for
nutritional interventions aimed at colon tumor prevention, and the
management of patients with colon cancer following resection in
conjunction with radiation or chemotherapy.

## Key facts

- **NIH application ID:** 3176230
- **Project number:** 2R01CA038177-04
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **SAM.gov UEI:** FBYMGMHW4X95
- **Principal Investigator:** SELWYN A BROITMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $167,596
- **Award type:** 2
- **Project period:** 1986-04-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176230

## Citation

> US National Institutes of Health, RePORTER application 3176230, LIPID DIET EFFECTS ON COLON TUMOR GROWTH AND METASTASES (2R01CA038177-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176230. Licensed CC0.

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