# COMPLIANCE WITH NICOTINE-BEARING CHEWING GUM

> **NIH NIH R01** · UNIVERSITY OF WATERLOO · 1987 · $14,500

## Abstract

The main objective of this study is to evaluate the impact of procedures
designed to improve patient compliance in smoking cessation with a
nicotine-bearing chewing gum (NCG) regimen.  NCG alone has been shown to
have compliance problems, so it will be compared to NCG administered with
compliance-increasing techniques.  Sixty physicians will be divided into
"NCG alone" or "NCG plus" compliance groups.  Followups will assess
adherence to the program and success in smoking cessation.  This phase of
the study will involve about 2520 patients.  An additional 360 patients
will participate in a side study to assess measures such as continual urges
to smoke, relapses, and reactions to gum use.

The investigation of physician compliance behavior is proposed by the
Department of Health Studies at the University of Waterloo (Ontario,
Canada) and by the Department of Family Medicine at McMaster University.
While behavioral science expertise exists at the former institution,
McMaster will provide personnel with backgrounds in family medicine and in
clinical epidemiology.  The consortium plans to manage the proposed study
by using a management committee of four key persons, who will meet
regularly to monitor all aspects of the study.  In addition, internal and
external consultants are proposed.

Because nicotine gum has been approved for prescription in Canada for some
four years, this randomized clinical trial proposes study of several
questions related to physician compliance over time:  1) although efficacy
of the gum has been established, what is its effectiveness; 2) will
specific instructions given by the physician and a series of follow-up
appointments be more effective in eliciting smoking cessation in this
"usual case" environment, e.g., where nicotine gum is no longer noteworthy;
and 3) will the planned formative and process evaluations confirm physician
behavior, and provide clues why certain procedures were more effective.

For the validation of the smoking cessation all volunteers will be recalled
one year after program initiation coincident with a point in time six
months after the last use of nicotine gum.  At that time saliva will be
collected and analyzed for cotinine.

## Key facts

- **NIH application ID:** 3176406
- **Project number:** 3R01CA038334-03S1
- **Recipient organization:** UNIVERSITY OF WATERLOO
- **SAM.gov UEI:** RHJRA5J1A2B5
- **Principal Investigator:** J ALLAN BEST
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $14,500
- **Award type:** 3
- **Project period:** 1984-09-30 → 1987-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176406

## Citation

> US National Institutes of Health, RePORTER application 3176406, COMPLIANCE WITH NICOTINE-BEARING CHEWING GUM (3R01CA038334-03S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176406. Licensed CC0.

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