# ACTIVATION OF HUMORAL AND CELL RESPONSES BY T CELLS

> **NIH NIH R01** · YALE UNIVERSITY · 1991 · $168,466

## Abstract

The focus of this proposal is to study the influence of
functionally distinct subsets of CD4 T lymphocytes on B cell and
macrophage activation and function.  Previous studies in this
laboratory have shown that CD4 T cells can be subdivided into two
functionally distinct subsets whose functional capabilities
correlate with the unique panel of cytokines each releases upon
activation.  Given that their functions appear quite distinct with
one subset playing a primary role in B cell activation, IgE
secretion, mast cell and eosinophil amplification and the other
subset mediating delayed type hypersensitivity responses, cytolysis
and macrophage activation, it would appear that each subset would
contribute to immunity against microorganisms which are either
extracellular or intracellular microorganisms, respectively.  The
present studies will address the following issues.

   1) What is the function of cloned and uncloned subsets of CD4
in B cell and macrophage activation in vivo and in vitro;

2) What is the lineage relationship between the two subsets
of T cells in terms of their effector function and phenotype if
individual subsets are used to reconstitute B or scid mice; and

3) Are experimental models exhibiting deficiency in a
particular type of immunity examples of deficiencies in the
effector functions provided by a subset of CD4 T cell.

## Key facts

- **NIH application ID:** 3176437
- **Project number:** 5R01CA038350-11
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** KIM BOTTOMLY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $168,466
- **Award type:** 5
- **Project period:** 1984-03-01 → 1994-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176437

## Citation

> US National Institutes of Health, RePORTER application 3176437, ACTIVATION OF HUMORAL AND CELL RESPONSES BY T CELLS (5R01CA038350-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176437. Licensed CC0.

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