# ONTOGENETIC DEVELOPMENT OF LYMPHOCYTES

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1987 · $269,174

## Abstract

The Ly-6 group of alloantigens is one example of cell-surface
antigen systems which are encoded by multigene families.  At
least five distinct Ly-6 antigens named Ly-6A, B, C, D and Th B
have been identified by us and others.  Decisive progress in the
biochemical and serological characterization of these antigens
strongly supports our working hypothesis of close structural
relationships between the Ly-6 antigens.  Direct support is
rendered by analysis at the DNA level with the first Ly-6 cDNA
probe available, which has confirmed the existence of multiple
cross-hybridizing Ly-6DNA sequences in the mouse genome.  The
other breakthrough was the demonstration in several
laboratories, including ours, that Ly-6.A antigens are important
modulators allied with T cell activation, thus providing for the
first time clues regarding the physiological role of Ly-6 for
lymphocytes.

In view of these new developments our project on the
immunogenetics of Ly-6 will be redefined as follows:  we will

1)  Analyse the Ly-6A and related genes in detail,
2)  Continue cellular immunological studies of Ly-6 using normal
cells and cloned cell lines to test the hypothesis that Ly-6 is a
signal modulator in cellular activation,
3)  Continue the biochemical characterization of Ly-6 proteins
to determine glycosylation and phosphorylation status and their
form of plasma membrane association,
4)  Look for Ly-6 involvement in multimolecular complexes on
the cell surface,
5)  Following the finding that Ly-6A is selectively induced by
interferon, study modulation of Ly-6 antigen and gene expression
by lymphokines on T cell, B cells and NK cells and correlate this
with functional responses.

## Key facts

- **NIH application ID:** 3176440
- **Project number:** 2R01CA038351-10
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** ULRICH G HAMMERLING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $269,174
- **Award type:** 2
- **Project period:** 1984-04-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176440

## Citation

> US National Institutes of Health, RePORTER application 3176440, ONTOGENETIC DEVELOPMENT OF LYMPHOCYTES (2R01CA038351-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176440. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*