# MOLECULES MEDIATING LYMPHOCYTE ATTACHMENT

> **NIH NIH R01** · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 1989 · $173,548

## Abstract

Preliminary data are presented which demonstrate the attachment of lymphoma
cells to attachment-promoting molecules such as fibronectin and serum
spreading factor.  Data are also discussed which indicate that normal
lymphocytes from the thymus interact with at least one of these
molecules--serum spreading factor.  It is proposed here to study the
interactions of lymphoid cells with known adhesion molecules.  A plan is
also presented for the identification of novel molecules involved in
mediating the attachment of normal lymphocytes.  The fact that normal bone
marrow cells attach to a monolayer of thymic epithelium indicates that such
molecules exist.  These molecules will be examined for structure, function,
and tissue distribution.  The hypothesis is that the selective attachment
of immature lymphocytes to molecules within the thymus probably modulates
their differentiation, path of migration, and response to external
stimuli.  Understanding these interactions will give insight into the
behavior and development of lymphocytes as well as possibly provide a
better understanding of the behavior of lymphoid tumors.  New methods which
involve the study of cell attachment to electrophoretically separated
proteins are proposed for studying this problem.  (LB)

## Key facts

- **NIH application ID:** 3176454
- **Project number:** 5R01CA038352-06
- **Recipient organization:** SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- **SAM.gov UEI:** PHMKYKKJLQS1
- **Principal Investigator:** MICHAEL D PIERSCHBACHER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $173,548
- **Award type:** 5
- **Project period:** 1984-03-15 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176454

## Citation

> US National Institutes of Health, RePORTER application 3176454, MOLECULES MEDIATING LYMPHOCYTE ATTACHMENT (5R01CA038352-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176454. Licensed CC0.

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