# ADVANCED CLINICAL ULTRASONIC TISSUE CHARACTERIZATION

> **NIH NIH R01** · RIVERSIDE RESEARCH INSTITUTE · 1987 · $558,141

## Abstract

Riverside Research Institute and the Columbia University College of
Physicians and Surgeons, Division of Ultrasound, propose to continue their
collaborative effort to further develop, refine, and expand advanced
clinical methods of ultrasonic tissue characterization for the liver,
kidney, and other abdominal organs such as the spleen and pancreas.  These
advanced methods will stem from current work utilizing digital spectral and
cepstral processing methods to assess tissue-characterizing parameters such
as attenuation and mean characteristic microstructural spacings in normal
and abnormal liver and kidney.  The proposed research will increase the
volume of tissue scanned and digitized in each examination, and will
increase the overall bandwidth of the digitized signals.  Digitized rf
signals will be stored permanently for continuing evaluation as new
hypotheses are developed and tested.  The tissue-characterization
parameters resulting from data processing will be placed in a data base and
subjected to statistical analyses to identify optimal examination
procedures, processing strategies, and characterization parameters.  New
parameters are expected to be developed such as spatial variability in
attenuation or tissue-element spacing.  To take into account the importance
of the spatial distribution of tissue-characterizing parameters, novel
imaging methods will be employed.  The large number of patients routinely
scanned in the Division of Ultrasound provides an ample pool of cases for
acquiring data on a broad range of clinically significant diseases and for
obtaining statistically meaningful results.  Engineering research and
development will be undertaken by Riverside Research Institute staff
members while patient examinations and clinical interpretations will be
performed by Columbia University personnel.

## Key facts

- **NIH application ID:** 3176522
- **Project number:** 5R01CA038400-07
- **Recipient organization:** RIVERSIDE RESEARCH INSTITUTE
- **SAM.gov UEI:** GP8DN2TLZKE5
- **Principal Investigator:** Ernest Joseph Feleppa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $558,141
- **Award type:** 5
- **Project period:** 1985-03-15 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176522

## Citation

> US National Institutes of Health, RePORTER application 3176522, ADVANCED CLINICAL ULTRASONIC TISSUE CHARACTERIZATION (5R01CA038400-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176522. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*