# ADVANCED CLINICAL ULTRASONIC TISSUE CHARACTERIZATION

> **NIH NIH R01** · RIVERSIDE RESEARCH INSTITUTE · 1989 · $413,991

## Abstract

Riverside Research Institute and the Columbia University College
of Physicians and Surgeons will continue their collaborative effort
to further develop, refine, and expand advanced clinical methods
of ultrasonic tissue characterization for the liver, kidney, and
other abdominal organs such as the spleen and pancreas.  These
advanced methods will stem from current work utilizing digital
spectral and cepstral processing methods to assess tissue-
characterization parameters such as attenuation.  The proposed
research will increase the volume of tissue scanned and digitized
in each examination.  Digitized rf signals will be stored
permanently for continuing evaluation as new hypotheses are
developed and tested.  The tissue-characterization parameters
resulting from data processing will be placed in a data base and
subjected to statistical analyses to identify optimal examination
procedures, processing strategies, and characterization
parameters.  New parameters are expected to be developed such
as spatial variability in attenuation or tissue-element spacing.  To
take into account the importance of the spatial distribution of
tissue-characterization parameters, novel imaging methods will
be employed.  The large number of patients routinely scanned
provides an ample pool of cases for acquiring data on a broad
range of clinically significant diseases and for obtaining
statistically meaningful results.  Engineering research and
development will be undertaken by Riverside Research Institute
staff members while patient examinations and clinical
interpretations will be performed by Columbia University
personnel.

## Key facts

- **NIH application ID:** 3176523
- **Project number:** 5R01CA038400-09
- **Recipient organization:** RIVERSIDE RESEARCH INSTITUTE
- **SAM.gov UEI:** GP8DN2TLZKE5
- **Principal Investigator:** Ernest Joseph Feleppa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $413,991
- **Award type:** 5
- **Project period:** 1985-03-15 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176523

## Citation

> US National Institutes of Health, RePORTER application 3176523, ADVANCED CLINICAL ULTRASONIC TISSUE CHARACTERIZATION (5R01CA038400-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176523. Licensed CC0.

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