# REGULATION OF THE HUMAN THY-1 GENE

> **NIH NIH R01** · HOSPITAL FOR JOINT DISEASES ORTHO INST · 1987 · $136,109

## Abstract

Thy-1 is a cell surface differentiation marker expressed
predominantly in the brain of many mammalian species including
man.  In some species, notably rats and mice.  Thy-1 is also
expressed on lymphoid tissue.  Its preferential expression on
synapses and its appearance during morphologic development of
the brain suggest that it may play a role in synapse formation.
The tissue-specific expression of Thy-1 and its variation in
patterns of expression among different species make Thy-1 an
ideal model for studying the fundamental mechanisms that
underlie gene regulation.  We propose to identify DNA sequences
that regulate the Thy-1 gene in a tissue-specific manner.
Recombinant DNA constructs will be used in transient and stable
transformation systems.  In addition, transgenic mice expressing
the human Thy-1 gene will be used to study the mechanisms
responsible for the differing patterns of Thy-1 expression in
different species.

## Key facts

- **NIH application ID:** 3176528
- **Project number:** 2R01CA038404-03A1
- **Recipient organization:** HOSPITAL FOR JOINT DISEASES ORTHO INST
- **Principal Investigator:** JACK SILVER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $136,109
- **Award type:** 2
- **Project period:** 1984-01-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176528

## Citation

> US National Institutes of Health, RePORTER application 3176528, REGULATION OF THE HUMAN THY-1 GENE (2R01CA038404-03A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176528. Licensed CC0.

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