# EFFECTOR AND SUPPRESSOR MECHANISM IN TUMOR IMMUNITY

> **NIH NIH R01** · EAST TENNESSEE STATE UNIVERSITY · 1990 · $88,715

## Abstract

Our studies on tumor immunity in vitro and in vivo led to the
observation that macrophages were generated in vivo in tumor
bearing mice and in vitro in spleen cell cultures.  The macrophages
are generated in several stages involving radiosensitive and radio-
resistant maturation.  They can be activated to inhibit tumor cell
growth in a local or contact dependent manner and can be activated
to produce monokines required for cellular immune responses.  T
cells can activate the macrophages by direct recognition of allo-
MHC determinants or by recognition of antigen in association with
self determinants.  Using T cell clones, flow cytometric sorting
of cells from primary lymphoid tissue, and in vitro culture
techniques, functionally distinct and maturationally distinct T
cell subpopulations are being evaluated for their ability to
activate monokine production and cytostatic activity in the
macrophage population and to become activated to produce
lymphokines.  The role of cognate and non-cognate T cell-macrophage
interactions in inducing these effector functions and in amplifying
cellular immune reactions are being investigated.

## Key facts

- **NIH application ID:** 3176544
- **Project number:** 5R01CA038408-06
- **Recipient organization:** EAST TENNESSEE STATE UNIVERSITY
- **SAM.gov UEI:** V5LLVC627U34
- **Principal Investigator:** ROBERT D STOUT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $88,715
- **Award type:** 5
- **Project period:** 1983-12-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176544

## Citation

> US National Institutes of Health, RePORTER application 3176544, EFFECTOR AND SUPPRESSOR MECHANISM IN TUMOR IMMUNITY (5R01CA038408-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176544. Licensed CC0.

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