# DIAGNOSIS OF LEUKEMIA (CML) ONCOGENE (C-ABL) EXPRESSION

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1987 · $99,432

## Abstract

The object of this project is to apply results of recent advances in
molecular biology, specifically molecular cloning of cellular oncogenes,
synthesis of oncogene related peptides, and in situ chromosome
hybridization to the diagnosis, evaluation, and monitoring of human
leukemias--specifically to chronic myelogenous leukemia (CML).  A novel 8
Kb RNA hybridizing with the normal, cellular homologue of the transforming
gene of Abelson murine leukemia virus (c-abl) has been detected in patients
with CML and the t(9,22) translocation (Ph' chromosome).  It is not present
in CML without the t(9,22) or other leukemias with rare exceptions.  We
will analyze patients with CML and related myeloproliferative disorders
(Ph' negative CML) for this novel c-abl RNA.  The objective is to define
more precisely the Ph' negative leukemia and to correlate c-abl expression
with disease phase and response to therapy.  These RNA studies are to be
complemented with analysis of c-abl related patients and by in situ
chromosome hybridization using a v-abl probe.  These studies will allow a
more precise (molecular) definition of CML and related human leukemias.  (6)

## Key facts

- **NIH application ID:** 3176620
- **Project number:** 5R01CA038569-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** ROBERT P GALE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $99,432
- **Award type:** 5
- **Project period:** 1985-06-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176620

## Citation

> US National Institutes of Health, RePORTER application 3176620, DIAGNOSIS OF LEUKEMIA (CML) ONCOGENE (C-ABL) EXPRESSION (5R01CA038569-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176620. Licensed CC0.

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