# INTERFERON PROPERTIES, ACTIONS, & PATIENT PRESCREENING

> **NIH NIH R01** · FORDHAM UNIVERSITY · 1993 · $181,342

## Abstract

Studies will be undertaken to gain further insight into the
mechanism of action of the interferons (IFNs).  Proposed studies
will characterize the antiviral and antiproliferative phenotypes
of cells which, as a result of transfection, produce the
IFN-induced gp96, 67kD, 56kD, or 42kD proteins.  In addition, the
cDNAs encoding these proteins will be used to: 1) study the genes
encoding these proteins; 2) characterize the promoters responsible
for their responsiveness to the IFNs; and 3) determine the
chromosomal localization of each gene.

Characterization of the IFN-induced 56,000 dalton protein has
resulted in the demonstration that this protein is a tryptophanyl
tRNA synthetase.  Studies proposed will evaluate the relatedness
of this protein to the mammalian peptide chain release factor and
the role this protein plays in the biological actions of the IFNs.

The characterizations of genes and their products that are
up-regulated in response to the IFNs are being undertaken to
provide insight into the mechanisms by which the IFNs mediate their
effects and to enable the development of a methodology by which the
responsiveness of tumor tissues to the anticellular effects of the
IFNs can be established in vitro prior to their use as therapeutic
agents.

## Key facts

- **NIH application ID:** 3176832
- **Project number:** 2R01CA038661-10A2
- **Recipient organization:** FORDHAM UNIVERSITY
- **SAM.gov UEI:** ECESTN2SSVH1
- **Principal Investigator:** Berish Y Rubin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $181,342
- **Award type:** 2
- **Project period:** 1989-09-30 → 1997-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176832

## Citation

> US National Institutes of Health, RePORTER application 3176832, INTERFERON PROPERTIES, ACTIONS, & PATIENT PRESCREENING (2R01CA038661-10A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176832. Licensed CC0.

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