# INTERFERONS--PROPERTIES, ACTION AND PATIENT PRESCREENING

> **NIH NIH R01** · FORDHAM UNIVERSITY · 1990 · $145,029

## Abstract

Studies will be undertaken to gain further insight into the mechanism of
action of the interferons and to ascertain how they can best be employed
therapeutically.  We are proposing to biochemically characterize those
proteins whose synthesis is induced following interferon treatment.  This
characterization will include the partial amino acid sequencing of these
proteins.  In addition to the induction of new proteins following interferon
treatment, other protein changes have been observed in cells whose growth is
inhibited by interferon treatment.  These changes will be studied and a
determination will be made as to whether they can be used to predict which
cells will be growth inhibited by interferon treatment.  If so,
methodologies will be developed which will allow for a determination of the
responsiveness of freshly removed tumor tissues to the effects of the
different human interferons.

To learn more about the effects of the interferons, a variety of cell lines
will be treated with the different interferons and their antiviral response,
against several different viruses, and their anticellular response will be
determined.  An attempt will then be made to correlate these effects with
the interferon induced enzymes and proteins produced by these cells.

The human interferons and tumor necrosis factors have been observed to
exhibit a synergistic antiproliferative effect and the antiviral effects of
the interferons have been observed to be enhanced by the tumor necrosis
factors.  Experiments will be undertaken to study these interactions to
determine the mechanism by which they occur.  This study is designed to
provide information which will allow for the optimal combined use of these
biological response modifiers in the clinic.

## Key facts

- **NIH application ID:** 3176837
- **Project number:** 5R01CA038661-08
- **Recipient organization:** FORDHAM UNIVERSITY
- **SAM.gov UEI:** ECESTN2SSVH1
- **Principal Investigator:** Berish Y Rubin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $145,029
- **Award type:** 5
- **Project period:** 1989-09-30 → 1992-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176837

## Citation

> US National Institutes of Health, RePORTER application 3176837, INTERFERONS--PROPERTIES, ACTION AND PATIENT PRESCREENING (5R01CA038661-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176837. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*