# RELATION OF BENIGN HYPERPLASIA TO CARCINOMA OF PROSTATE

> **NIH NIH R01** · BROWN UNIVERSITY · 1988 · $180,060

## Abstract

The long-term goal of this study is to develop knowledge of the
relationship of prostatic hyperplasia (BPH) and prostatic cancer.  The
principal specific aims are evaluation of the prostatic cancer mortality
rate subsequent to surgically-confirmed BPH and comparison of prostatic
cancer incidence and death rates according to histologic features of BPH.
A retrospective follow-up study is proposed.  A population-based group of
6,000 men with surgically-confirmed BPH will be identified by use of
pathology records in Rhode Island hospitals state-wide.  Subjects will have
had their index admission in the period 1959-70, and will have been less
than 75 years old at that time.  The cohort will be followed up by use of
medical records, death certificates, city directories, and other existing
resources.  Slides of the benign tissue will be retrieved for all the cases
of prostatic cancer that are identified, and for a sample of 3 times that
number of non-cases.  The slides will be reviewed according to a standard
protocol in order to assess the features of the hyperplastic tissue,
especially the epithelial component, and other benign changes.  The death
rate from prostatic cancer in the cohort will be compared to the rate
experienced by Rhode Island men of similar ages.  By use of the
case-control within a cohort approach, the incidence and mortality rates
from prostatic cancer will be correlated with histologic features of the
benign tissue removed.  Death rates from other causes also will be
evaluated.  The findings will bear on the natural history of prostatic
hyperplasia, and on the clinical prognosis of men with this condition.

## Key facts

- **NIH application ID:** 3176926
- **Project number:** 5R01CA038707-03
- **Recipient organization:** BROWN UNIVERSITY
- **SAM.gov UEI:** E3FDXZ6TBHW3
- **Principal Investigator:** ALAN S. MORRISON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $180,060
- **Award type:** 5
- **Project period:** 1985-12-01 → 1989-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3176926

## Citation

> US National Institutes of Health, RePORTER application 3176926, RELATION OF BENIGN HYPERPLASIA TO CARCINOMA OF PROSTATE (5R01CA038707-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3176926. Licensed CC0.

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