# STUDIES ON EPITECTIN AND RELATED GLYCOPROTEINS

> **NIH NIH R01** · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 1991 · $161,854

## Abstract

The cell surface has been one of the focal points in the studies on
malignancy.  General changes in structures of cell surface glycoconjugates
as well as the presence of unique glycoconjugates in malignant cell surface
have been reported.  The long-range objective of this study is to
contribute to the structure-function relationships of cancer cell surface
glycoproteins and malignancy.  The emphasis will be on the high molecular
weight cell surface sialoglycoproteins (termed Ca antigen) which are
detectable by Cal monoclonal antibody on a wide variety of human malignant
cells.  The primary objective is to carry out full biochemical
characterization of the Ca antigen.  Cal monoclonal antibody will be
employed as affinity ligand for the isolation of the Ca antigen from human
laryngeal carcinoma cells.  The 390K and 350K species of the Ca antigen
will be purified and their detailed chemical structure elucidated.  The
carbohydrate and protein composition, oligosaccharide type and location,
and subunit structure are some of the aspects which will be studied.  The
counterpart of Ca antigen from human melanoma cells and the Ca antigen-like
glycoproteins present in normal human urine will also be purified.  The
structural and immunological relationships of these materials and Ca
antigen will be established.  Polyclonal and monoclonal antibodies to the
purified Ca antigen glycoproteins will be produced and used for
understanding the above relationship.  It is hoped that the information
obtained in these studies will help to establish the potential use of Ca
antigen as a human tumor marker.  This glycoprotein antigen could be of use
for the early diagnosis of cancer, for monitoring the course of disease,
for localizing tumors, and for directing drugs to the tumor.  (1)

## Key facts

- **NIH application ID:** 3177106
- **Project number:** 5R01CA038797-05
- **Recipient organization:** PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- **SAM.gov UEI:** TNKGNDAWB445
- **Principal Investigator:** VEER P. BHAVANANDAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $161,854
- **Award type:** 5
- **Project period:** 1984-12-01 → 1994-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177106

## Citation

> US National Institutes of Health, RePORTER application 3177106, STUDIES ON EPITECTIN AND RELATED GLYCOPROTEINS (5R01CA038797-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177106. Licensed CC0.

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