# CHARACTERIZATION OF THE V-ERB B ONCOGENE PROTEIN OF AEV

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA AT DAVIS · 1990 · $116,918

## Abstract

The ultimate goal of the experiments proposed here is a better
understanding of the molecular mechanisms by which the v-erb B
oncogene of avian erythroblastosis virus transforms host cells to
an oncogenic state.  Functional domains within the v-erb B gene
product will be identified and the specific roles these different
domains play in establishing the transformed phenotype will be
determined by use of site-directed mutagenesis and recombinant
DNA techniques.  Specific aspects of three broad questions will be
addressed:

A.  What specific features of the v-erb B protein are responsible
for the target cell specificity of this oncogene?  A genetic
dissection of this phenomenon is proposed.

B.  Is the v-erb polypeptide subject to the same regulatory
processes operative on its normal cell progenitor, the EGF-
receptor (c-erb B protein)?  This question seeks to better
understand the molecular and biochemical basis behind the
"activation" of the mitogenic EGF-receptor into the oncogenic v-
erb B protein.

C.  What is the site of action of the v-erb B protein in the
transformed cell?  This question has important implications for
identifying the location, and the nature, of the host cell "target"
polypeptides which must interact with the v-erb B protein to
mediate oncogenic transformation.

These experiments will provide novel information on the
mechanism of action of v-erb B in viral-mediated oncogenesis.  In
addition, due to the close inter-relatedness between the v-erb B
protein and the host cell EGF-receptor, these experiments will
help in understanding the relationship between processes
regulating growth and proliferation in normal and neoplastic cells.

## Key facts

- **NIH application ID:** 3177186
- **Project number:** 5R01CA038823-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **SAM.gov UEI:** TX2DAGQPENZ5
- **Principal Investigator:** Martin L. Privalsky
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $116,918
- **Award type:** 5
- **Project period:** 1985-07-01 → 1993-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177186

## Citation

> US National Institutes of Health, RePORTER application 3177186, CHARACTERIZATION OF THE V-ERB B ONCOGENE PROTEIN OF AEV (5R01CA038823-06). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3177186. Licensed CC0.

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