# EPIDEMIOLOGY/BIOLOGY OF CHILDHOOD NON-HODGKIN'S LYMPHOMA

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1990 · $15,743

## Abstract

The major aims of the study are to characterize childhood NHL with
respect to chromosomal abnormalities and immunologic phenotype, and
to relate the findings of these studies to etiologic factors
derived from case/control interviews and EBV viral studies.  The
interviews will focus on immune-related disorders in the family of
the patient, and unusual or chronic antigenic exposures of the
patient.  This is an extension to a study that is expected to reach
its initial goals of total patient accrual, but will fall short
with respect to accrual of the important subgroup of patients who
have tumor tissue available for study.  The specific aims for the
next two years are to include an additional 80 patients into this
subgroup.

Incident cases of NHL, enrolled on therapeutic studies of the
Children's Cancer Study Group, will be eligible.  Biopsy material
from these children will be used for cytogenetic analyses,
immunopathology studies, histopathology, and EBV serology.  Serum
will be frozen for future use.  The mothers of cases, and a matched
control group selected by random digit dialling, will be
interviewed by telephone to provide data on familial associations,
particularly of immune-related conditions such as autoimmune
disease and allergy, and on environmental exposures of the child
and parents.

It is hoped that this study will provide a clearer understanding
of the interrelations of viruses, chromosomal abnormalities, and
genetic and acquired immune function disturbances in childhood NHL.

## Key facts

- **NIH application ID:** 3177353
- **Project number:** 5R01CA038908-05
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** Jonathan Buckley
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $15,743
- **Award type:** 5
- **Project period:** 1985-09-30 → 1992-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177353

## Citation

> US National Institutes of Health, RePORTER application 3177353, EPIDEMIOLOGY/BIOLOGY OF CHILDHOOD NON-HODGKIN'S LYMPHOMA (5R01CA038908-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177353. Licensed CC0.

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