# IRON CHELATES FOR CONTRAST ENHANCEMENT IN NMR IMAGING

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1990 · $290,129

## Abstract

The overall aim of the proposed renewal is to test, in preclinical
and in clinical experiments, the safety and efficacy of iron-
containing pharmaceuticals for obtaining added information from
magnetic resonance imaging and spectroscopy.  The specific aims
are threefold.  First, study of newly selected agents will be
undertaken by (a) screening selected paramagnetic iron chelates
of hydroxamate, catecholate, phenolate and hydroxpyridonate
ligands; and (b) exploring paramagnetic and superparamagnetic
particulates.  Second, continued study of selected agents from
years 01-03 is proposed by (a) clinically measuring elimination,
metabolic fate, and pharmacokinetics for agents from three
biodistribution classes (ferrioxamine B, Fe-HBED, and magnetic
AMI-25); (b) clinically assessing safety and efficacy of Fe-HBED
and ferrioxamine B; (c) comparatively evaluating different
enhancement agents for diagnosis of focal hepatic disease, and (d)
comparatively evaluating efficacy of different relaxation agents
for 31P MRS signal localization and enhancement.  Third, the
added benefit of T2, T2- and susceptibility-sensitive imaging
techniques will be studied.  By obtaining this data, progress will
be made toward more complete understanding of magnetic
resonance technology.  Practical agents for image enhancement in
several organ systems will be introduced.  More refined uses,
some previously considered poorly feasible, will be developed for
spectroscopy and for tumor-, inflammation-, and flow-targeting.
Investigative methods include (a) chemical synthesis and analysis;
(b) pharmaceutical formulation and quality assurance; (c) nuclear
magnetic resonance imaging, spectroscopy, and relaxometry; and
(d) nuclear medicine radioanalogue detection methods.

## Key facts

- **NIH application ID:** 3177371
- **Project number:** 5R01CA038918-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** BARRY L ENGELSTAD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $290,129
- **Award type:** 5
- **Project period:** 1985-01-01 → 1991-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177371

## Citation

> US National Institutes of Health, RePORTER application 3177371, IRON CHELATES FOR CONTRAST ENHANCEMENT IN NMR IMAGING (5R01CA038918-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177371. Licensed CC0.

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