# ASSESSMENT OF SELENIUM STATUS IN MAN

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1990 · $219,100

## Abstract

A new method is proposed for the assessment of body selenium
status in man.  The method is based on in vivo Stable Isotope
Dilution (in vivo SID) concept.

It is proposed that the validity of the method be established with
a combination of human and animal model experiments.  The
animal model experiments will focus on validating the method in
relation to true changes in whole-body and organ selenium
contents of the animals.  The experiments will establish the
expected correlation between this and the functional index of
selenium status based on tissue levels of GSH-Px, in the
nutritional range os selenium intakes.

The human experiments are designed to investigate the
quantitative relationship between the proposed index the expected
changes in urine excretion of selenium and the measured balance
of selenium over the range of selemium intakes  relevant to both
nutritional requirements and supplementation.  In addition, the
correlation, or lack thereof, between the proposed index and
platelet GSH-Px over the nutritionally relevant range of intake
will be established.  Furthermore, in the supplemental range of
selenium intake, the expected positive correlation between the
proposed index and increased synthesis and elimination of TMSe
(TriMethyl Selenonium) will be tested.

Both animal and human studies will permit exploration of the
effect of the chemical form of the label (selenite vs.
selenomethionine) on the validity of the method.  It is expected
that selenite will prove as the suitable form of the label for these
purposes,

## Key facts

- **NIH application ID:** 3177463
- **Project number:** 5R01CA038943-06
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** MORTEZA JANGHORBANI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $219,100
- **Award type:** 5
- **Project period:** 1987-12-01 → 1991-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177463

## Citation

> US National Institutes of Health, RePORTER application 3177463, ASSESSMENT OF SELENIUM STATUS IN MAN (5R01CA038943-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177463. Licensed CC0.

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