# QUANTITATIVE MODEL OF HUMAN PANCREAS CARCINOGENESIS

> **NIH NIH R01** · SUNY DOWNSTATE MEDICAL CENTER · 1988 · $54,161

## Abstract

Preneoplastic steps such as metaplasia, hyperplasia, and atypia are
considered pathological steps in the development human carcinoma.
Multiphasic oncogene activation during carcinogenesis is shown to occur in
malignant neoplasia.  Oncogene activation is usually determined by
morphological transformation of NIH3T3 cells.  It is proposed to
demonstrate the activation of oncogenes in tumors induced in human pancreas
explants, to determine and compare the temporal relationship between the
activation of the oncogene and morphological steps in pancreas
carcinogenesis.

It is further proposed to develop a system for detection of oncogene
activation other than NIH3T3 cells.  This model will be based on the
morphological transformation of human pancreas cell lines in vitro and
their tumorigenicity in "athymic nude" mice in vivo.

## Key facts

- **NIH application ID:** 3177489
- **Project number:** 3R01CA038955-03S1
- **Recipient organization:** SUNY DOWNSTATE MEDICAL CENTER
- **SAM.gov UEI:** NJ14V2NZYM68
- **Principal Investigator:** JOSEF MICHL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $54,161
- **Award type:** 3
- **Project period:** 1985-07-01 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177489

## Citation

> US National Institutes of Health, RePORTER application 3177489, QUANTITATIVE MODEL OF HUMAN PANCREAS CARCINOGENESIS (3R01CA038955-03S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177489. Licensed CC0.

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