# ANTAGONISTS FOR CIS-PLATINUM NEPHROTOXICITY

> **NIH NIH R01** · VANDERBILT UNIVERSITY · 1990 · $120,713

## Abstract

The goal of the proposed research is to examine the use of dithiocarbamate
chelating agents (which we have recently prepared) in controlling the
nephrotoxicity of cis-platinum at normal and elevated dosage levels.  Renal
function in experimental animals (rats) will be monitored (via measurement
of serum creatinine levels and blood urea nitrogen values) as the animals
are taken through various protocols designed to allow the administration of
cis-platinum under conditions selected to produce minimum nephrotoxicity.
These same protocols will be examined for anti-tumor efficacy in the rat
using cis-platinum sensitive Walker 256 carcinosarcoma (ATCC)(CL38) to
determine the effect of the measures used to reduce nephrotoxicity on the
anti-cancer activity of the cis-platinum.  Analogous studies will be
carried out using other transplantable tumors in rats and mice (70).
Dose-response curves will be developed to determine the effect of chelating
agent dosage on the course of blood urea nitrogen levels, serum creatine
values and platinum mobilization.  The chelating agents which we plan to
use are primarily ones which we have prepared and shown to be capable of
reducing the nephrotoxicity of cis-platinum without altering the
anti-cancer activity significantly, in the Walker 256 model system, though
structurally related compounds will also be examined.  Experimental
determination of the effect of these chelating agents on the cytotoxicity
of cis-platinum will also be carried out as preliminary results indicate
that perhaps only part of the reduction in nephrotoxicity which has been
observed is due to chelation.

## Key facts

- **NIH application ID:** 3177598
- **Project number:** 5R01CA038997-05
- **Recipient organization:** VANDERBILT UNIVERSITY
- **SAM.gov UEI:** GTNBNWXJ12D5
- **Principal Investigator:** MARK M JONES
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $120,713
- **Award type:** 5
- **Project period:** 1986-04-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177598

## Citation

> US National Institutes of Health, RePORTER application 3177598, ANTAGONISTS FOR CIS-PLATINUM NEPHROTOXICITY (5R01CA038997-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177598. Licensed CC0.

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